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Affiliation Company of Real Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Scientific Base, This new Taipei Area, Taiwan

Affiliations Division out of Rheumatology, Sensitivity, and Immunology, Company away from Inner Treatments, Kaohsiung Chang Gung Art gallery Healthcare, Kaohsiung, Taiwan, Chang Gung University School from Drug, Kaohsiung, Taiwan

Affiliations Chang Gung College College out of https://sugar-daddies.net/sugar-daddies-usa/ Medicine, Kaohsiung, Taiwan, Agencies away from Obstetrics and you will Gynecology, Kaohsiung Chang Gung Art gallery Medical, Kaohsiung, Taiwan

Affiliations Division away from Rheumatology, Sensitivity, and you may Immunology, Institution off Interior Medication, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Chang Gung School College away from Medication, Kaohsiung, Taiwan

  • Fu-Mei Su,
  • Dung-Huan Liu,
  • Jia-Feng Chen,
  • Shan-Fu Yu,
  • Wen-Chan Chiu,
  • Chung-Yuan Hsu,

Record

To develop an enthusiastic OSTAi device and you may contrast that it towards the Federal Weakening of bones Base advice into the 2013 (NOF 2013) to own limbs mineral density (BMD) review certainly one of Taiwan postmenopausal lady.

Strategies

Taiwan Weakening of bones Relationship (TOA) held a national BMD questionnaire by the a coach strung having a beneficial twin times X-ray absorptiometry (DXA) between 2008 and you will 2011. Most of the professionals accomplished survey, which included class and you can risk activities off osteoporotic break inside the FRAX tool. We utilized the databases to analyze prospective exposure situations to own osteoporosis and you may used the fresh new design by Koh mais aussi al. growing a threat index via multiple changeable regression investigation and item cures. We used the directory philosophy to arrange a straightforward algorithm (particularly OSTAi) to determine those who you want BMD aspect. Receiver working characteristic (ROC) contour in addition to town within the curve (AUC) was used to compare brand new awareness/specificity study of this model with this from advice from the NOF 2013.

Abilities

A total of several,175 Taiwan postmenopausal ladies enrolled in this questionnaire. The brand new directory really worth try derived of the years and the body weight from the players based on weighted likelihood of for every single risk foundation and you may the newest picked cutoff worth is actually set from the “-1”. You will find 6393 (52.5%) participants whoever directory value is below “-1” and whose likelihood of weakening of bones is actually 57.5% (). This new AUC to own OSTAi and you may NOF 2013 was 0.739 (95% count on interval (CI), 0.728–0.749, P 2 ), earlier crack, risky cures fool around with on the lowest limbs mass otherwise bone loss (age.g., glucocorticoid in a daily amounts ? 5 mg prednisone or comparable to possess ? 3 months), or disease or reputation of bone loss (age.grams., rheumatoid arthritis). The new diagnostic show out-of NOF 2013 to own anticipating osteoporosis in our examined people ended up being assessed.

Mathematical Research

I adopted the new mathematical studies because of the Koh mais aussi al. which includes amendment. The potential risk situations to possess weakening of bones included in the design creativity process consisted of the risk situations from the FRAX device, in which cultural basis was not included.

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