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Knowledge-based about three-human body potential for transcription factor binding web site prediction

A structure-built analytical potential are set up getting transcription basis binding website (TFBS) forecast. Together with the head contact between amino acids out-of TFs and you may DNA bases, this new people plus considered new determine of your own neighbouring feet. Which three-looks prospective demonstrated most useful discriminate efforts compared to the several-looks prospective. It validate the new abilities of the potential during the TFBS character, joining times anticipate and you can binding mutation forecast.

1 Introduction

Protein–DNA relationships gamble extremely important positions in lot of physiological processes. Více