• NLRC5-mediated MHC group We expression when you look at the cancers

    Numerous training playing with Nlrc5-lacking mice exhibited the newest critical into the vivo role off NLRC5 inside the MHC classification We-founded antigen presentation

    This new reliance away from MHC group We phrase into NLRC5 is verified of the observation from impaired expression regarding classical and you may non-ancient MHC class-I genetics (H2Db, H2Kb, H2-M3, H2-Qa1, and Tla) and you can genetics employed in MHC class I antigen presentation routes such as because the ?2m, Tap1, Lmp2 throughout the thymus and spleen from Nlrc5-lacking mice [30, thirty two, 34, 40]. Více

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